Doctors and caregivers rely on the latest studies and verifiable information to guide decisions to diagnose and prescribe Cannabis Based Medical Extracts (CBMEs) to treat specific diseases and their symptoms. The information offered here is based on rigorous clinical studies, registered U.S. patents, and reliable anecdotal evidence obtained from patients, treating physicians, and medical professionals.
This page is designed for medical professionals to better understand cannabis culture terms like strains and potency, while categorically identifying the uses of prominent cannabinoids that have been successfully used in treatment for certain diseases. The importance of reliable dosage offers care givers substantial guidelines for responsible and effective patient treatments.
CBMEs for Reliable and Precise Titration
A CBME is a scientifically produced tincture. Tinctures offer the best way to deliver nutrients in stable soluble form, optimal for assimilation. Tinctures retain volatile and semi volatile ingredients, usually lost in heat treated and especially reprocessed dry extracts. The importance of these ingredients for health beneficial action is hard to overestimate.
Due to convenient dosing, tinctures are one of the safest herbal preparations on the market. They are easy to adjust to individual habits and metabolism. High bio availability, achieved through complete dissolution of healthy ingredients, is one of the most beneficial features of the tinctures. It is especially useful when the absorption of vitamins and nutrients by the body is reduced, due to natural causes (age or malfunctions of the digestive system).
CBS Science tinctures include ethanol which is proven to be the most effective, according to recent medical study shown in the sidebar. Glycerites are frequently used as a substitute for alcohol. Science proves that glycerin by itself is not a good carrier of THC and CBD. Unlike alcohol, that has quick access to the liver, glycerin is approximately 30% slower in absorption by the digestive tract and is utilized through a secondary pathway in the liver (known as the ‘gluconeogenic’ pathway).
Creating a CBME
We start with “Safe Cannabis” certified medical grade Northern California “total plant” materials. We capture the “total plant” medicinal properties using a state of the art organic re flux extraction process. Once the extraction is complete, it is then sent in to the lab for potency testing.
Organically grown hypo-allergic, gluten free, 190 proof neutral grape spirits is used to extract the medicine. Organic neutral grape spirits is the most efficient medium for both capturing and assimilating the medicine.
Based on the results of the lab work, we refine the extract to desired potency (10 mg/ml THC for “Euphoria” 5 mg/ml THC and 5 mg/ml CBD for “Tranquility” and 1 mg/ml THC and 10 mg/ml CBD for “Healing”). Honey, botanical-based flavors, and spring water is added for flavoring and consistency.
What methods of delivery do your tinctures use?
Our tinctures are delivered using two distinctly different delivery methods: Digestive and sublingual. Digestive delivery is for patients who are looking for prolonged relief and a powerful deep experience. Sublingual delivery is for patients who require quick relief.
What Happens with Each Delivery Method?
If you ingest it “sublingually”, by using the spray or dropper and placing the correct amount under your tongue, the majority of active herbal alkaloids are absorbed through the mucous system into your blood stream very quickly. The remaining alkaloids are absorbed into your blood stream via the digestive system. This method of delivery is fast, it generates a smooth, gentle experience, lasting 2-3 hours.
If you ingest it “digestively”, by drinking the correct amount, all the alkaloids are absorbed into your blood via your digestive system. This method of delivery is not as fast as the “sublingual” method, it is “deeper” and longer lasting, and it generates a consistent deep experience and lasts 4-6 hours. Ingesting CBMEs via the digestive system produces heightened psychoactivity compared to sublingually ingested tincture.
Why is the “digestive” experience “deeper” than a “sublingual” experience?
Once swallowed, a tincture passes from the stomach to the small intestine before being absorbed into the bloodstream (for a tincture this process happens faster than a typical editable). Following absorption, the tincture passes through the liver where a significant proportion of the drug is metabolized into other chemicals (1). One of these chemicals, 11-hydroxy-THC, may be four to five times more potent than natural THC(2), and is produced in greater quantities (3) (4). Thus, patients administered a tincture “digestively” experience the psychoactive effects of both THC and 11-hydroxy-THC.
(1) J. Morgan and L. Zimmer, Marijuana Myths, Marijuana Facts: A Review of the Scientific Evidence. The Lindesmith Center. 1997: 18-19.
(2) L. Lemberger et al. 1973. Comparative pharmacology of delta-9-THC and its metabolite 11-0H-Delta-9-THC. Journal of Clinical Investigation 54: 2411-2417 and M. Perez-Reyes et al. 1972. Intravenous injection in man of delta-9-tetrahydrocannabinol and 11-hydroxy-delta-9-tetrahydrocannabinol. Science 177: 633-635 as cited by J. Morgan and L. Zimmer, Marijuana Myths, Marijuana Facts: A Review of the Scientific Evidence.
(3) E. Russo, M.D., Cannabis: from Pariah to Prescription, 2003: page 10.
(4) Ibid; J. Morgan & L. Zimmer, Marijuana Myths, Marijuana Facts: A Review of the Scientific Evidence